TOTAL SYNTHESES OF MOKKO LACTONE, DEHYDROCOSTUS LACTONE, AND EREMANTHIN

Costunolide and Dehydrocostus Lactone as T Lymphocytes Inhibitors of Killing Function of Cytotoxic

7-butyro)actone is required for the inhibitery effect. Costunolide marked]y inhibited the granule exocytosis and the production of inositol phosphates in response to anti-CD3 monoclonal antibody (mAb) stimu]ation at a concentration that did not affect the binding of anti-CD3 mAb. Tyrosine phosphorylation induced by crosslinking of CD3 molecules was significantly inhibited by costunolide in a do...

The Antiinflammatory Sesquiterpene Lactone

Microbial β‐lactone natural products

Microbial b-lactone natural products An annotated selection of World Wide Web sites relevant to the topics in microbial biotechnology. Obafluorin is an antimicrobial b-lactone compound produced by the bacterium Pseudomonas fluorescens. In this study, the compound was synthesized, analysed chemically and tested for biological activity. The triedimycins are a class of spiro b-lactones. They are n...

2-C-Phenyl­erythrono-1,4-lactone

THE TITLE COMPOUND (SYSTEMATIC NAME 3,4-dihydr-oxy-3-phenyl-furan-2-one), C(10)H(10)O(4), features a five-membered γ-lactone ring with an envelope conformation at the C atom carrying the hydr-oxy group without the phenyl substituent. In the crystal, supra-molecular chains mediated by O-H⋯O hydrogen bonding are formed along the a-axis direction. These are consolidated in the crystal structure by...

Galactaro δ-Lactone Isomerase: Lactone Isomerization by a Member of the Amidohydrolase Superfamily

Agrobacterium tumefaciens strain C58 can utilize d-galacturonate as a sole source of carbon via a pathway in which the first step is oxidation of d-galacturonate to D-galactaro-1,5-lactone. We have identified a novel enzyme, D-galactarolactone isomerase (GLI), that catalyzes the isomerizaton of D-galactaro-1,5-lactone to D-galactaro-1,4-lactone. GLI, a member of the functionally diverse amidohy...